Osteoarthritis In osteoarthritis (OA), the protective cartilage inside the joint breaks down. This makes movement of affected joints more difficult and painful. In time, bones of the joint may rub directly against one another, causing severe pain. Pain can also come from parts of your joint other than the cartilage, such as bone, synovium and ligaments. Rheumatoid Arthritis In rheumatoid arthritis (RA), the joints and other organs are attacked by the body’s own immune system. The immune system normally protects a person from viruses, bacteria and other invaders. In people with autoimmune diseases like RA, it becomes overactive and attacks healthy tissue. Psoriatic Arthritis Psoriatic arthritis (PsA) is an autoimmune inflammatory disease in which the immune system attacks the body, causing inflammation and pain. PsA affects the joints, causing arthritis; the connective tissue where tendons or ligaments attach to bones, causing enthesitis; and the skin, causing psoriasis
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